Paul was hindered by satan many times in many different ways, but, specifically, the last time Paul and Silas were in Thessalonica, satan hindered them from visiting the church in Thessalonica by creating a riot.
In Acts 17:1-10, Paul was in Thessalonica, where there was a synagogue of the Jews. The synagogue was where Scripture was debated, more than where worship took place. For three Sabbaths in a row, Paul debated with the different sects of Jews, trying to convince them Jesus is the Christ.
Some of the leading women were convinced and a lot of Greeks who were in the Jewish faith believed, but the Jews who refused to believe Jesus is the Messiah became angry. These Jews were mainly Pharisees and Sadducees who often pitted people against each other in an attempt to uphold their belief system and keep their lifestyle intact.
These Jews took evil men from the marketplace and gathered together a mob to start a riot. They turned the town upside down and attacked the house of Jason where Paul and Silas were staying. This mob had intentions to bring Paul and Silas outside to the people so Paul and Silas could get beat down.
Paul and Silas were not there so the mob dragged Jason and some of the other Christians out of the house and took them to the rulers of the city screaming, “These who have turned the world upside down have come here too. Jason has harbored them, and these all are acting contrary to the decrees of Caesar, saying there is another king—Jesus.”
This put Paul and Silas in danger, so, they had to be secretly escorted out of the city to safety, causing Paul and Silas to not reach the church at Thessalonica in person. Paul eventually wrote letters to them instead, 1 Thessalonians being the first of his fourteen epistles.